Center for Environmental Systems Microbiology

What is "Systems Microbiology"?


what is systems microbiology image

Seeks to discover how microbial functions evolve and respond & how emergent properties in single cells and complex microbial communities arise

Microbial life has been closely intertwined with natural environmental systems for nearly the entire history of Earth. Their small size and spectacularly diverse metabolic activities permit microorganisms to inhabit an extreme range of niches.

Microorganisms inhabit all terrestrial and aquatic ecosystems (i.e., coastal and deep sea, Antarctic dry valleys, subsurface contaminated with radioactive elements (and 1 in 10 ‘human’ cells is a microbial cell).

Microorganisms exert a tremendous influence on the entire biosphere, e.g., transferring energy and materials across complex biotic and abiotic interfaces, controlling biogeochemical cycles and affecting geology, hydrology and climate patterns at local and global scales.

Interactions between microbes and their environment are dominated by a complex network of biological, chemical and physical processes occurring at scales ranging from nano- to ecosystem scale.

3 ‘systems’ levels:  1) molecular 2) cellular   3) community
Examples of research needs:
•     Understanding microbial community function in natural habitats, responses to environmental changes
•     Developing strategies for harnessing microbial metabolic diversity
 (vast and largely untapped)
•     New approaches to protein identification and characterization in single cells and complex microbial communities
•     New methods for the characterization of molecular machines and their functions
•     New computational tools to exploit available microbial genome sequences